Minggu, 29 September 2019

Zantac: CVS latest to suspend heartburn drug over cancer fears - BBC News

US retailer CVS has become the latest to suspend the sale of a heartburn drug being investigated for links to cancer.

It follows concern in several countries over the presence of impurities in Zantac and other ranitidine products.

Canada and France have already announced Zantac recalls. The US and the European Union are investigating.

Health authorities say there is no immediate risk, but patients have been advised to consult a doctor who can prescribe alternatives to ranitidine.

What is the fear about?

On 13 September, both the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) published their decisions to review the presence of N-nitrosodimethylamine (NDMA) in medicines containing the drug ranitidine.

NDMA is classified as a probable human carcinogen (a substance that could cause cancer) on the basis of animal studies.

NDMA is found in water and foods, including meats, dairy products, and vegetables, but is not expected to cause harm when ingested in very low levels, EMA says.

Ranitidine products are used to reduce the production of stomach acid in patients with conditions such as heartburn and stomach ulcers.

They are available over-the-counter and on prescription.

Who has recalled the products so far?

CVS's announcement on Saturday said it was suspending the sale of Zantac and CVS Health brand ranitidine products "out of an abundance of caution".

"Zantac brand products and CVS brand ranitidine products have not been recalled, and the FDA is not recommending that patients stop taking ranitidine at this time," the company said.

Walgreens, Walmart and Rite Aid in the US had earlier taken a similar decision.

Canada and France have removed the drugs from pharmacy shelves. A number of other countries have followed suit.

Drug makers are also recalling products containing NDMA.

Sandoz, owned by Novartis, told the BBC it was recalling "several batches of its ranitidine-containing medicines". The recalls were "under way or pending" in Australia, Austria, Belgium, Canada, Croatia, the Czech Republic, Denmark, Finland, Germany, Hungary, Macedonia, Portugal, Slovakia, Slovenia, Sweden, Switzerland and the US.

Apotex also said it was recalling ranitidine tablets in the US.

The BBC has approached GlaxoSmithKline - original makers of Zantac. The company is reported to have stopped distributing its generic version of the drug and recalled its products from India and Hong Kong.

What should patients do?

Health regulators are urging people taking ranitidine not do discontinue it immediately.

The FDA said, however, that those taking it by prescription should contact health professionals about alternatives. And those buying it over the counter could consider other options.

French authorities also emphasised there was no "acute risk" and patients should not stop the medication or return it to pharmacies.

Let's block ads! (Why?)


https://www.bbc.com/news/health-49868852

2019-09-29 09:11:36Z
CBMiKGh0dHBzOi8vd3d3LmJiYy5jb20vbmV3cy9oZWFsdGgtNDk4Njg4NTLSASxodHRwczovL3d3dy5iYmMuY29tL25ld3MvYW1wL2hlYWx0aC00OTg2ODg1Mg

Sabtu, 28 September 2019

Illegal cannabis vape carts tested positive for poisonous cyanide - Business Insider

Vape cartridgeA disposable cannabis vape cartridge.Ben Gilbert/Business Insider

  • In a test of cannabis vape cartridges conducted by NBC News, 15 out of 15 illegal carts contained a fungicide that, when burned, can turn into hydrogen cyanide — a extremely dangerous poison.
  • All the legal vape carts tested were deemed safe.
  • In addition to the fungicide, 13 out of 15 contained Vitamin E — a solvent that's used to cut cannabis vapes.
  • Visit Business Insider's homepage for more stories.

Vaping, once thought to be a safe alternative to smoking, is facing increasing scrutiny over an increasingly visible health crisis: 530 total possible cases of vape-related lung illness, according to the CDC.

And it's not just cigarette smoking that has people turning to vaping — cannabis, too, is available in vape form. But, like so many black market items before it, the world of illegal weed vapes is tainted with the potential for dangerous additives that could hurt users.

A recent NBC News study documented exactly how real that potential danger is: Of the 15 black market cannabis vape carts NBC had tested, 13 came back positive for containing Vitamin E acetate — a solvent used to cut cannabis that, when it gets in your lungs, could trigger an immune response that causes pneumonia.

Even worse: Of the illegal carts NBC tested, all 15 tested positive for myclobutanil — a fungicide that, when burned, can turn into hydrogen cyanide. 

cura cannabis solutions select oil vape 1Legal cannabis vape cartridges at a production facility.Facebook/selectstrains

It's not all bad news — NBC News also tested three cannabis vape cartridges from a legal dispensary in California, all from different manufacturers.

All three came back clean, with the testing facility having found "no heavy metals, pesticides, or residual solvents like Vitamin E."

But with no federal-level regulation for cannabis vape carts, and legality of cannabis so balkanized, it's difficult to regulate dangerous additives in vape carts. As the federal government struggles to regulate the quickly emerging market, it's offering a straightforward solution that should work for anyone: Reconsidering buying and using a black market vape cart.

"If you're thinking of purchasing one of these products off the street, out of the back of a car, out of a trunk, in an alley," Mitch Zeller, the director of the FDA's Center for Tobacco Products, said recently, "or if you're going to go home and make modifications to the product yourself using something that you purchased from some third party or got from a friend, think twice."

Digital Health Pro

Featured Digital Health Articles:
- Telehealth Industry: Benefits, Services & Examples
- Value-Based Care Model: Pay-for-Performance Healthcare
- Senior Care & Assisted Living Market Trends
- Smart Medical Devices: Wearable Tech in Healthcare
- AI in Healthcare
- Remote Patient Monitoring Industry: Devices & Market Trends

Let's block ads! (Why?)


https://www.businessinsider.com/illegal-weed-vapes-laced-with-poison-2019-9

2019-09-28 14:01:08Z
52780396195170

Vaping risks scare local teens, but many are too addicted to quit - The Philadelphia Inquirer

Vaping has consumed the lives of teens across the country, students say, many to the point of addiction. Juuls in particular, the rectangular devices that look more like a USB drive than an e-cigarette, lurk in the background of nearly every aspect of many teens’ conversations, school day, and social lives. Schools are enforcing strict rules to curb their use, placing vape detectors around campus, assigning staff to monitor hallways and bathrooms, making kids sign contracts against vaping, and meeting with parents to try to deter what government and health officials are calling an epidemic.

Let's block ads! (Why?)


https://www.inquirer.com/news/vaping-juul-e-cigarettes-health-effects-teens-addiction-20190928.html

2019-09-28 09:02:29Z
52780394628298

9 ex-Tesla employees reveal the worst parts of working there - Business Insider

tesla employeeNine former Tesla employees, who worked at the company between 2008 and this year, described to Business Insider their least favorite parts of their jobs.Spencer Platt / Getty Images

Like many companies engaged in a highly competitive business, Tesla is not always an easy place to work. From long hours to the stress of working under CEO Elon Musk, a job at the electric-car maker can be demanding.

Nine former employees who worked at the company between 2008 and 2019 described their least favorite parts of their jobs. Each asked for anonymity due to a fear of reprisal from Tesla.

Here's what they said.

The photos in this story do not depict the former Tesla employees Business Insider interviewed.

Are you a current or former Tesla employee? Do you have an opinion about what it's like to work there? Contact this reporter at mmatousek@businessinsider.com.

Let's block ads! (Why?)


https://www.businessinsider.com/ex-tesla-employees-reveal-the-worst-parts-of-working-there-2019-9

2019-09-28 13:23:09Z
52780395148870

China Markets to Test the Risk of Most Extreme U.S. Threat Yet - Bloomberg

[unable to retrieve full-text content]

  1. China Markets to Test the Risk of Most Extreme U.S. Threat Yet  Bloomberg
  2. White House deliberates block on all US investments in China  CNBC
  3. UPDATE 7-Trump considers delisting Chinese firms from U.S. markets -sources  Yahoo Finance
  4. ‘This Is Huge’ as China Threat Dents Markets: Wall Street Reacts  Bloomberg
  5. White House mulling ban on US investment in China  Washington Examiner
  6. View full coverage on Google News

https://www.bloomberg.com/news/articles/2019-09-28/china-markets-to-test-the-risk-of-most-extreme-u-s-threat-yet

2019-09-28 07:51:00Z
52780395518411

Jumat, 27 September 2019

Delta's LATAM Investment: The 7 Losers - One Mile at a Time

Yesterday I wrote about the truly shocking development that Delta would buy a stake in LATAM, and as a result LATAM would cut ties with American and oneworld. This was all happening while American and LATAM were pursuing a joint venture, though they were having problems getting regulatory approval in Chile.

The extent to which this came out of left field, and the extent to which this largely reshapes the global airline industry in so many ways, can’t be understated.

In this post I wanted to take a closer look at who the “losers” are in this situation:

In this post:

American

It sure seems like American was blindsided by this. The airline is trying to downplay the severity of what happened. American says that they understand LATAM’s decision, and that their current relationship provided less than $20 million of incremental revenue to American. That’s probably technically true, though doesn’t fully underscore the extent to which this decision is going to be negative for them.

It’s true that American and LATAM were struggling to get their joint venture approved, and they would have had so many restrictions that it would have only been marginally worthwhile.

The real loss here doesn’t come in the form of incremental revenue loss, but rather from American and oneworld going from the dominant airline and alliance in the region, to now being a distant second:

  • American has generally been scaling back operations in South America, especially to secondary markets
  • American is left without a partner airline in South America, so they have few connection opportunities beyond their major hubs there
  • It’s true that Miami is the key gateway to South America, and American is still strong there, though keep in mind that LATAM also has flights to 10 destinations from Miami, so in many ways they can compete there

It’s going to be very interesting to see how American acts going forward. I’m curious if they just sort of largely concede Latin America, or if they ramp up operations and try to compete with the Delta & LATAM partnership.

The thing is, American actually could be very competitive, given they have Miami as a key gateway. But the question is whether or not Latin America is a lucrative enough market for them as of now, or whether American management can be forced to wake up and take action on anything.

Oneworld

LATAM is leaving oneworld, and that’s a huge loss for the alliance. While oneworld has some awesome airlines, and while they have great recognition for elite members, oneworld will have a huge hole in their network.

In Latin America Star Alliance has Avianca and Copa, while SkyTeam at least has Aerolineas Argentinas. Oneworld will have nothing.

SkyTeam

This might come as a surprise, but I actually think SkyTeam loses with this as well. While LATAM is leaving oneworld, there are no indications that they’re joining SkyTeam, and that’s bad news for SkyTeam.

Delta management has increasingly been talking about how they don’t see value in SkyTeam.

As Delta continues building their own global network of airlines without them joining SkyTeam, it increasingly deemphasizes the value of the alliance.

Gol

A few years ago Delta bought a stake in and formed a partnership with Brazilian airline Gol. This was an attempt for Delta to get some sort of a presence in Brazil, though obviously they’re not the ideal partner if you’re trying to build a global alliance.

It has been announced that Delta will be dropping their stake in Gol, so we can expect that that partnership will end soon as well.

Alaska

Alaska has a global network of partner airlines, and for years they’ve partnered with LATAM. It has been great to be able to earn and redeem Alaska Mileage Plan miles for travel on LATAM.

While nothing has been formally announced, I’d be willing to bet that Delta will force LATAM to cut ties with Alaska.

Delta and Alaska are sort of enemies at this point (they used to be frenemies), given how fiercely they’ve been competing in Seattle. So the precedent has been that as Delta gets closer to airlines, they magically cut ties with Alaska.

Savvy Consumers

I don’t want to say that consumers on the whole lose out because of this new partnership, though I do think it’s fair to say that savvy consumers will lose out.

In many ways, American and LATAM were exactly where I wanted them. I was happy their joint venture wasn’t approved, since it meant there was more competition in the marketplace.

But for savvy consumers, I ultimately do think LATAM was better where they are now than where they will be:

  • LATAM is currently in a global alliance, meaning that people from around the world can easily earn and redeem miles on them
  • The global alliances do offer a lot of consumer benefits, like lounge access, priority check-in, and more

While Delta will no doubt offer reciprocal benefits:

  • They likely won’t have nearly as many global partners
  • Delta often restricts benefits to specific circumstances/types of tickets (in other words, despite Delta’s big investment in both airlines, I doubt Virgin Atlantic elite members will get access to LATAM lounges when flying the airline domestically)

Qatar Airways

There aren’t really practical implications here, but it is still noteworthy. Qatar Airways owns a 10% stake in LATAM. Delta and Qatar Airways hate one another. Qatar Airways CEO Akbar Al Baker constantly talks about Delta, and their “granny” flight attendants, and their “sh!t aeroplanes.”

Purely in terms of ego, I can’t imagine Al Baker is all too happy that his friends in Atlanta just purchased a bigger share of the airline than Qatar owns. I’d be shocked if Al Baker wasn’t emptying out his piggy bank today to see if he can buy more, because he doesn’t want to be second place to anything compared to Mr. Bastian.

Bottom Line

Delta’s investment in LATAM is possibly the biggest airline acquisition news in the US since the merger spree we saw among US airlines (which started with Delta & Northwest and ended with Alaska & Virgin America).

This is big in so many ways — in terms of the amount spent, in terms of the implications this has for the global alliances, and in the sense that Delta literally stole LATAM from American and oneworld, and is in the process throwing Gol by the wayside.

What’s your take as to who the losers are with Delta’s investment in LATAM?

Let's block ads! (Why?)


https://onemileatatime.com/deltas-latam-investment-losers/

2019-09-27 11:19:48Z
52780394998368

It doesn’t matter that Peloton shares tumbled on their first day: Morning Brief - Yahoo Finance

Friday, September 27, 2019

Get the Morning Brief sent directly to your inbox every Monday to Friday by 6:30 a.m. ET. Subscribe

Why Peloton's IPO was a huge success

Peloton went public on Thursday.

Shares of the interactive exercise platform operator priced at $29 on Wednesday and finished Thursday’s trading session at $25.76, good for an 11.2% decline on its first day of trading.

This decline in the stock on its first day of trading could be framed as a disappointment. Bloomberg notes, for instance, that was the third-worst public debut of the last decade.

This price action might indicate that investors aren't excited about Peloton's prospects and that the struggles of consumer tech IPOs this year will continue. Some may also ask if this means the IPO window is closing. Have the struggles at The We Company spread into other offerings? And if the whole market of a successful IPO is seeing shares pop on the first day, then surely this is a failure, right?

Well, as far as famed VC investor Bill Gurley sees it, the first-day IPO pop is the most misunderstood and financially nonsensical event that a management — and investors and the media — team could root for.

Speaking with Patrick O'Shaugnessy on the Invest Like the Best podcast this week, Gurley took to task the idea that "successful" IPOs are ones in which a company’s stock trades sharply higher on the first day of trading.

"Thinking that a pop is a marketing event is about the most short-term oriented decision a manager or CEO/CFO could think," Gurley said. "Because it happens and it's over. And then the rest of your corporate life is based on how the company performs. And the notion that I'd get some lasting benefit by paying $500 million for this marketing event flies in the face of long term thinking."

Gurley cites an analogy about homebuying he heard from Henry Blodget — imagine selling your house and then hearing your broker sold the home for 80% more the next day. Now imagine celebrating that. This is what is happening when first-day IPO pops are cheered. It is a celebration that makes no economic sense.

Companies that see shares pop on the first day of trading leave money on the table. Money that could've been used to invest in the business. And the founders, employees, and early investors in a company that sell shares into the IPO also lose money — potentially hundreds of millions of dollars — if the stock goes nuts on the first day of trading. The only stakeholders excited about a first-day IPO pop are the investors who were fortunate enough to get an allocation the day before the IPO and then flipped these shares and the bankers who will now be able to earn fees on a future secondary offering of stock.

To take a real world example from this year, anyone that sold Beyond Meat (BYND) shares into the IPO sold shares at $25; when the market closed on Beyond's first day of trading, those shares were worth $65.75. So a Beyond Meat executive, for example, that sold $1 million worth of Beyond Meat stock into the IPO lost out on more than $1.6 million in potential gains.

Peloton IPO (Reuters)
Peloton IPO (Reuters)

But guess who did benefit? The investors who got an IPO allocation of Beyond and flipped it on day one and the bankers that got to participate in Beyond's secondary offering in late July.

In other words, the winner of Beyond Meat's IPO wasn't Beyond Meat.

Now, certainly the bankers that run IPO processes don't do nothing. You cannot have well-paid, well-connected finance professionals market your company and connect with investors for free. And as with many things in financial markets, the psychology of events can matter as much as the economics of an event. So if the psychology of an IPO that sinks on its first day of trading is thought to indicate that the company's prospects are bad, then the economic benefit for a company that prices its IPO higher than where it opens for trade might be ignored by investors.

Gurley's solution for companies is to favor direct listings. In a direct listing — which we've seen from Spotify (SPOT) and Slack (WORK) recently — companies don't lean on a team of bankers to drum up support for shares at a certain price.

Instead, the company says it will list shares on a certain exchange on a certain date and then shares begin trading. The newly-public company does not raise any money or issue any new shares. Of course, the problem with direct listings is that they make bankers a whole lot less money.

But the goal of an IPO isn't to enrich bankers or to make shares trade higher. The goal of an IPO is to raise money and offer liquidity to early shareholders who had been sitting on illiquid positions. The price the market sets for shares after they start trading does not — or at least, should not, and certainly need not — matter to the company.

Because in the end, a good company will be respected by the market over the long term. As Gurley reminds listeners, Facebook (FB), Amazon (AMZN), and Alphabet (GOOGL) "broke issue" and traded below their IPO price. And I think we'd all agree these companies have done well by their shareholders.

By Myles Udland, reporter and co-anchor of The Final Round. Follow him @MylesUdland

What to watch today

Economy

  • 8:30 a.m. ET: Personal Income, August (0.4% expected, 0.1% in July); Personal Spending, August (0.3% expected, 0.6% in July)

  • 8:30 a.m. ET: Durable Goods Orders, August preliminary (-1.2% expected, 2.0% in July); Durables excluding Transportation, August preliminary (0.3% expected, -0.4% in July);

  • 10 a.m. ET: University of Michigan Sentiment, September final (92.1 expected, 92.0 prior)

From Yahoo Finance

  • Season 4 of the popular NBC drama “This is Us” premiered on Tuesday. Today at 5 p.m. ET Yahoo Finance will reprise the My Three Cents installment in which The Final Round co-anchor Jen Rogers interviews “This is Us” star Chrissy Metz, who speaks candidly about growing up poor and about how she keeps a close eye on her finances to ensure she never lives in poverty again.

Read more

Top News

ZHOUSHAN, CHINA - SEPTEMBER 01: Aerial view of a Cosco France container ship berthing with the help of tugboats at the Port of Ningbo-Zhoushan on September 1, 2019 in Zhoushan, Zhejiang Province of China. The Cosco France container ship, coming from Singapore, will unload 8,015 twenty-foot equivalent unit (TEU) containers at the Port of Ningbo-Zhoushan. (Photo by Yao Feng/VCG via Getty Images)
ZHOUSHAN, CHINA - SEPTEMBER 01: Aerial view of a Cosco France container ship berthing with the help of tugboats at the Port of Ningbo-Zhoushan on September 1, 2019 in Zhoushan, Zhejiang Province of China. The Cosco France container ship, coming from Singapore, will unload 8,015 twenty-foot equivalent unit (TEU) containers at the Port of Ningbo-Zhoushan. (Photo by Yao Feng/VCG via Getty Images)

Global oil shipping rates soar as U.S. supertanker sanctions rattle crude trade [Reuters]

Pound plunges after Bank of England policymaker signals rate cut [Yahoo Finance UK]

Endeavor abandons IPO amid market pushback [Reuters]

DoorDash hack leaks data of 4.9 mln customers, restaurants [Reuters]

YAHOO FINANCE HIGHLIGHTS

Markets would soar, not crash, if Trump got impeached

JPMorgan is bullish on this 'universally hated and cheap sector'

Marijuana banking law could create new opportunities for Main St. investors

Follow Yahoo Finance on Twitter, Facebook, Instagram, Flipboard, SmartNews, LinkedIn, YouTube, and reddit.

Let's block ads! (Why?)


https://finance.yahoo.com/news/peloton-ipo-success-shares-fall-103249581.html

2019-09-27 10:32:00Z
52780393697805